Drug interactions
Fenoprofen + Vortioxetine
Severity: Moderate
Fenoprofen and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine affects platelet serotonin uptake, and fenoprofen inhibits platelet function and irritates the gastric lining. Combined use may increase the risk of bruising and gastrointestinal or other bleeding.
What this interaction means in plain words
Fenoprofen and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive impairment of platelet function through serotonin reuptake inhibition and NSAID COX-1 inhibition.
What to do
Monitor for bleeding and consider gastroprotection in patients who are older or have prior ulcer disease. Prefer a non-NSAID analgesic such as paracetamol where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Fenoprofen with Vortioxetine?
MediHelp rates the interaction as moderate. Fenoprofen and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine affects platelet serotonin uptake, and fenoprofen inhibits platelet function and irritates the gastric lining. Combined use may increase the risk of bruising and gastrointestinal or other bleeding.
How serious is the interaction between Fenoprofen and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider gastroprotection in patients who are older or have prior ulcer disease. Prefer a non-NSAID analgesic such as paracetamol where possible.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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