Drug interactions
Fentanyl + Hydrochlorothiazide-irbesartan
Severity: Minor
Fentanyl and Hydrochlorothiazide-irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as fentanyl can cause hypotension and may add to blood pressure lowering from antihypertensives. Reduced diuretic effect from opioid-related antidiuretic hormone release is possible but not well established.
What this interaction means in plain words
Fentanyl and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fentanyl belongs to Musculoskeletal; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Additive hypotensive effects, with possible opioid-induced ADH release and urinary retention reducing diuretic efficacy.
What to do
Monitor blood pressure and fluid status, particularly at initiation and with dose increases. Watch for urinary retention in susceptible patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as minor. Fentanyl and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids such as fentanyl can cause hypotension and may add to blood pressure lowering from antihypertensives. Reduced diuretic effect from opioid-related antidiuretic hormone release is possible but not well established.
How serious is the interaction between Fentanyl and Hydrochlorothiazide-irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and fluid status, particularly at initiation and with dose increases. Watch for urinary retention in susceptible patients.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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