Drug interactions
Fentanyl + Idebenone
Severity: Moderate
Fentanyl and Idebenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idebenone mildly inhibits CYP3A4, which is the main pathway of fentanyl metabolism. Fentanyl levels could rise, increasing the risk of sedation and respiratory depression.
What this interaction means in plain words
Fentanyl and Idebenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Idebenone belongs to Central Nervous System.
Why it happens
Mild CYP3A4 inhibition reduces fentanyl clearance.
What to do
Monitor for sedation and respiratory depression and consider reducing the fentanyl dose when starting idebenone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Idebenone
- Aliskiren + Idebenone Moderate
- Cyclosporin + Idebenone Moderate
- Dabigatran etexilate + Idebenone Moderate
- Digoxin + Idebenone Moderate
- Idebenone + Tacrolimus Moderate
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Idebenone?
MediHelp rates the interaction as moderate. Fentanyl and Idebenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idebenone mildly inhibits CYP3A4, which is the main pathway of fentanyl metabolism. Fentanyl levels could rise, increasing the risk of sedation and respiratory depression.
How serious is the interaction between Fentanyl and Idebenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and consider reducing the fentanyl dose when starting idebenone.
What other medicines interact with Idebenone?
MediHelp also lists interactions of Idebenone with, for example, Aliskiren, Cyclosporin, Dabigatran etexilate. The full list is on the Idebenone page.
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