Drug interactions
Idebenone + Tacrolimus
Severity: Moderate
Idebenone and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idebenone may modestly increase tacrolimus concentrations through CYP3A4 inhibition. Because tacrolimus has a narrow therapeutic window, this may lead to nephrotoxicity or neurotoxicity.
What this interaction means in plain words
Idebenone and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idebenone belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
Mild CYP3A4 inhibition reduces tacrolimus metabolism.
What to do
Check tacrolimus trough levels and renal function after starting or stopping idebenone and adjust the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Idebenone
- Aliskiren + Idebenone Moderate
- Cyclosporin + Idebenone Moderate
- Dabigatran etexilate + Idebenone Moderate
- Digoxin + Idebenone Moderate
- Fentanyl + Idebenone Moderate
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Idebenone with Tacrolimus?
MediHelp rates the interaction as moderate. Idebenone and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idebenone may modestly increase tacrolimus concentrations through CYP3A4 inhibition. Because tacrolimus has a narrow therapeutic window, this may lead to nephrotoxicity or neurotoxicity.
How serious is the interaction between Idebenone and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check tacrolimus trough levels and renal function after starting or stopping idebenone and adjust the dose as needed.
What other medicines interact with Idebenone?
MediHelp also lists interactions of Idebenone with, for example, Aliskiren, Cyclosporin, Dabigatran etexilate. The full list is on the Idebenone page.
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