Drug interactions
Dabigatran etexilate + Idebenone
Severity: Moderate
Dabigatran etexilate and Idebenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idebenone may inhibit P-glycoprotein, which limits dabigatran absorption and promotes its efflux. Higher dabigatran exposure may increase the risk of bleeding.
What this interaction means in plain words
Dabigatran etexilate and Idebenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Idebenone belongs to Central Nervous System.
Why it happens
P-gp inhibition increases dabigatran etexilate absorption and reduces efflux.
What to do
Monitor for bleeding signs and renal function, and consider a lower dabigatran dose in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Idebenone
- Aliskiren + Idebenone Moderate
- Cyclosporin + Idebenone Moderate
- Digoxin + Idebenone Moderate
- Fentanyl + Idebenone Moderate
- Idebenone + Tacrolimus Moderate
Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Frequently asked questions
Can I take Dabigatran etexilate with Idebenone?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Idebenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idebenone may inhibit P-glycoprotein, which limits dabigatran absorption and promotes its efflux. Higher dabigatran exposure may increase the risk of bleeding.
How serious is the interaction between Dabigatran etexilate and Idebenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and renal function, and consider a lower dabigatran dose in patients with renal impairment.
What other medicines interact with Idebenone?
MediHelp also lists interactions of Idebenone with, for example, Aliskiren, Cyclosporin, Digoxin. The full list is on the Idebenone page.
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