Drug interactions
Cyclosporin + Idebenone
Severity: Moderate
Cyclosporin and Idebenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idebenone is a mild CYP3A4 inhibitor and may raise cyclosporine concentrations. Cyclosporine has a narrow therapeutic index, so increases can cause nephrotoxicity and hypertension.
What this interaction means in plain words
Cyclosporin and Idebenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Idebenone belongs to Central Nervous System.
Why it happens
Mild inhibition of CYP3A4-mediated cyclosporine metabolism.
What to do
Monitor cyclosporine trough levels and renal function when idebenone is started or stopped, and adjust the cyclosporine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Idebenone
- Aliskiren + Idebenone Moderate
- Dabigatran etexilate + Idebenone Moderate
- Digoxin + Idebenone Moderate
- Fentanyl + Idebenone Moderate
- Idebenone + Tacrolimus Moderate
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Idebenone?
MediHelp rates the interaction as moderate. Cyclosporin and Idebenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idebenone is a mild CYP3A4 inhibitor and may raise cyclosporine concentrations. Cyclosporine has a narrow therapeutic index, so increases can cause nephrotoxicity and hypertension.
How serious is the interaction between Cyclosporin and Idebenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function when idebenone is started or stopped, and adjust the cyclosporine dose accordingly.
What other medicines interact with Idebenone?
MediHelp also lists interactions of Idebenone with, for example, Aliskiren, Dabigatran etexilate, Digoxin. The full list is on the Idebenone page.
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