Drug interactions
Digoxin + Idebenone
Severity: Moderate
Digoxin and Idebenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idebenone may inhibit P-glycoprotein and raise digoxin exposure. Digoxin has a narrow therapeutic index, so higher levels could cause arrhythmias, nausea and visual disturbances.
What this interaction means in plain words
Digoxin and Idebenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Idebenone belongs to Central Nervous System.
Why it happens
P-gp inhibition reduces digoxin intestinal and renal efflux.
What to do
Monitor serum digoxin concentrations and ECG after starting or stopping idebenone, and reduce the digoxin dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Idebenone
- Aliskiren + Idebenone Moderate
- Cyclosporin + Idebenone Moderate
- Dabigatran etexilate + Idebenone Moderate
- Fentanyl + Idebenone Moderate
- Idebenone + Tacrolimus Moderate
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Idebenone?
MediHelp rates the interaction as moderate. Digoxin and Idebenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idebenone may inhibit P-glycoprotein and raise digoxin exposure. Digoxin has a narrow therapeutic index, so higher levels could cause arrhythmias, nausea and visual disturbances.
How serious is the interaction between Digoxin and Idebenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations and ECG after starting or stopping idebenone, and reduce the digoxin dose if levels rise.
What other medicines interact with Idebenone?
MediHelp also lists interactions of Idebenone with, for example, Aliskiren, Cyclosporin, Dabigatran etexilate. The full list is on the Idebenone page.
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