Drug interactions
Fentanyl + Omaveloxolone
Severity: Moderate
Fentanyl and Omaveloxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone may induce CYP3A4 and lower exposure to sensitive substrates such as fentanyl. This could reduce pain relief.
What this interaction means in plain words
Fentanyl and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Omaveloxolone belongs to Central Nervous System.
Why it happens
Omaveloxolone induces CYP3A4, increasing fentanyl metabolism.
What to do
Monitor for reduced analgesia and titrate fentanyl as needed. Reassess the dose when omaveloxolone is stopped, because fentanyl levels may then rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Fentanyl with Omaveloxolone?
MediHelp rates the interaction as moderate. Fentanyl and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone may induce CYP3A4 and lower exposure to sensitive substrates such as fentanyl. This could reduce pain relief.
How serious is the interaction between Fentanyl and Omaveloxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced analgesia and titrate fentanyl as needed. Reassess the dose when omaveloxolone is stopped, because fentanyl levels may then rise.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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