Drug interactions
Fentanyl + Opicapone
Severity: Minor
Fentanyl and Opicapone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opicapone is a COMT inhibitor used in Parkinson disease and can cause somnolence and dizziness. Added to fentanyl, it may modestly increase drowsiness, although the effect is generally limited.
What this interaction means in plain words
Fentanyl and Opicapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fentanyl belongs to Musculoskeletal; Opicapone belongs to Central Nervous System.
Why it happens
Possible additive sedation; no established pharmacokinetic interaction.
What to do
Be aware of possible additive drowsiness and counsel patients about driving and operating machinery. No dose adjustment is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Opicapone
- Isocarboxazid + Opicapone Contraindicated
- Opicapone + Phenelzine Contraindicated
- Opicapone + Tranylcypromine Contraindicated
- Adrenaline-articaine + Opicapone Moderate
- Asenapine + Opicapone Moderate
- Dobutamine + Opicapone Moderate
Frequently asked questions
Can I take Fentanyl with Opicapone?
MediHelp rates the interaction as minor. Fentanyl and Opicapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opicapone is a COMT inhibitor used in Parkinson disease and can cause somnolence and dizziness. Added to fentanyl, it may modestly increase drowsiness, although the effect is generally limited.
How serious is the interaction between Fentanyl and Opicapone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of possible additive drowsiness and counsel patients about driving and operating machinery. No dose adjustment is usually needed.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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