Drug interactions
Fentanyl + Ozanimod
Severity: Moderate
Fentanyl and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolites inhibit MAO-B in vitro, and fentanyl has weak serotonergic activity. Serotonin syndrome or hypertensive reactions are theoretically possible with this combination. Clinical data are limited.
What this interaction means in plain words
Fentanyl and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Ozanimod belongs to Central Nervous System.
Why it happens
Possible MAO inhibition by ozanimod metabolites combined with fentanyl serotonergic activity, which is predicted rather than well established.
What to do
Monitor for signs of serotonin toxicity such as agitation, tremor, hyperthermia and clonus, and for blood pressure changes. Stop the combination if these appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Fentanyl with Ozanimod?
MediHelp rates the interaction as moderate. Fentanyl and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's active metabolites inhibit MAO-B in vitro, and fentanyl has weak serotonergic activity. Serotonin syndrome or hypertensive reactions are theoretically possible with this combination. Clinical data are limited.
How serious is the interaction between Fentanyl and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity such as agitation, tremor, hyperthermia and clonus, and for blood pressure changes. Stop the combination if these appear.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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