Drug interactions
Fentanyl + Repotrectinib
Severity: Major
Fentanyl and Repotrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib is a CYP3A4 inducer and may speed fentanyl metabolism, reducing analgesic effect. When repotrectinib is discontinued, fentanyl exposure can climb, with a risk of overdose.
What this interaction means in plain words
Fentanyl and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fentanyl belongs to Musculoskeletal; Repotrectinib belongs to Oncology.
Why it happens
CYP3A4 induction by repotrectinib increases fentanyl clearance.
What to do
Monitor analgesic response and withdrawal, and adjust the fentanyl dose or choose a non-CYP3A4 opioid. After stopping repotrectinib, monitor for sedation and respiratory depression and reduce the dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Fentanyl with Repotrectinib?
MediHelp rates the interaction as major. Fentanyl and Repotrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Repotrectinib is a CYP3A4 inducer and may speed fentanyl metabolism, reducing analgesic effect. When repotrectinib is discontinued, fentanyl exposure can climb, with a risk of overdose.
How serious is the interaction between Fentanyl and Repotrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and withdrawal, and adjust the fentanyl dose or choose a non-CYP3A4 opioid. After stopping repotrectinib, monitor for sedation and respiratory depression and reduce the dose.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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