Drug interactions
Fentanyl + Rucaparib
Severity: Minor
Fentanyl and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and may modestly increase fentanyl exposure. The clinical effect is usually small but could increase sedation.
What this interaction means in plain words
Fentanyl and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fentanyl belongs to Musculoskeletal; Rucaparib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 by rucaparib reduces fentanyl clearance.
What to do
Monitor for increased sedation or respiratory depression when starting rucaparib. Lower the fentanyl dose if excess opioid effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Fentanyl with Rucaparib?
MediHelp rates the interaction as minor. Fentanyl and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and may modestly increase fentanyl exposure. The clinical effect is usually small but could increase sedation.
How serious is the interaction between Fentanyl and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation or respiratory depression when starting rucaparib. Lower the fentanyl dose if excess opioid effects appear.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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