Drug interactions
Fentanyl + Sevoflurane
Severity: Moderate
Fentanyl and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane and fentanyl cause additive CNS, respiratory and cardiovascular depression. This combination is routinely used in anesthesia, but enhanced hypotension, bradycardia and prolonged respiratory depression can occur.
What this interaction means in plain words
Fentanyl and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS and respiratory depression; opioids lower the volatile anesthetic concentration required.
What to do
Titrate the anesthetic and opioid doses to effect under continuous monitoring of ventilation, oxygenation and hemodynamics. Ensure airway support and monitoring continue into recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Fentanyl with Sevoflurane?
MediHelp rates the interaction as moderate. Fentanyl and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane and fentanyl cause additive CNS, respiratory and cardiovascular depression. This combination is routinely used in anesthesia, but enhanced hypotension, bradycardia and prolonged respiratory depression can occur.
How serious is the interaction between Fentanyl and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate the anesthetic and opioid doses to effect under continuous monitoring of ventilation, oxygenation and hemodynamics. Ensure airway support and monitoring continue into recovery.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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