Drug interactions
Fentanyl + Stiripentol
Severity: Moderate
Fentanyl and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces CYP3A4, so its effect on fentanyl exposure is unpredictable and can lead to either toxicity or loss of analgesia. It also adds sedation, which compounds opioid-related respiratory depression.
What this interaction means in plain words
Fentanyl and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction altering fentanyl clearance, plus additive CNS depression.
What to do
Monitor analgesic effect and signs of oversedation or respiratory depression, and adjust the fentanyl dose accordingly. Reassess when stiripentol is started, stopped or changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Fentanyl with Stiripentol?
MediHelp rates the interaction as moderate. Fentanyl and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces CYP3A4, so its effect on fentanyl exposure is unpredictable and can lead to either toxicity or loss of analgesia. It also adds sedation, which compounds opioid-related respiratory depression.
How serious is the interaction between Fentanyl and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic effect and signs of oversedation or respiratory depression, and adjust the fentanyl dose accordingly. Reassess when stiripentol is started, stopped or changed.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
Full monographs, dosing and an interaction checker in the MediHelp app
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