Drug interactions
Fentanyl + Tedizolid
Severity: Moderate
Fentanyl and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tedizolid is a weak reversible MAO inhibitor and fentanyl has serotonergic activity, so serotonin syndrome is theoretically possible. Clinical studies with tedizolid showed little serotonergic effect at therapeutic doses.
What this interaction means in plain words
Fentanyl and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Tedizolid belongs to Anti Bacterial.
Why it happens
Weak reversible MAO inhibition by tedizolid combined with serotonergic activity of fentanyl.
What to do
Monitor for signs of serotonin syndrome such as agitation, clonus and hyperthermia during coadministration. Stop one agent if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Frequently asked questions
Can I take Fentanyl with Tedizolid?
MediHelp rates the interaction as moderate. Fentanyl and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tedizolid is a weak reversible MAO inhibitor and fentanyl has serotonergic activity, so serotonin syndrome is theoretically possible. Clinical studies with tedizolid showed little serotonergic effect at therapeutic doses.
How serious is the interaction between Fentanyl and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome such as agitation, clonus and hyperthermia during coadministration. Stop one agent if symptoms occur.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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