Drug interactions
Fentanyl + Vigabatrin
Severity: Moderate
Fentanyl and Vigabatrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vigabatrin can cause somnolence and fatigue, which can add to fentanyl's sedative effects. Combined use may impair alertness and coordination.
What this interaction means in plain words
Fentanyl and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Vigabatrin belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective fentanyl dose and monitor for excess sedation. Advise patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Vigabatrin
- Amisulpride + Vigabatrin Moderate
- Asenapine transdermal + Vigabatrin Moderate
- Asenapine + Vigabatrin Moderate
- Avapritinib + Vigabatrin Moderate
- Benzhydrocodone / acetaminophen + Vigabatrin Moderate
- Brexanolone + Vigabatrin Moderate
Frequently asked questions
Can I take Fentanyl with Vigabatrin?
MediHelp rates the interaction as moderate. Fentanyl and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vigabatrin can cause somnolence and fatigue, which can add to fentanyl's sedative effects. Combined use may impair alertness and coordination.
How serious is the interaction between Fentanyl and Vigabatrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective fentanyl dose and monitor for excess sedation. Advise patients to avoid driving until the response is known.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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