Drug interactions
Fentanyl intranasal + Hydrochlorothiazide-irbesartan
Severity: Minor
Fentanyl intranasal and Hydrochlorothiazide-irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can cause hypotension and may blunt diuretic effect via antidiuretic hormone release, while also causing urinary retention. Additive blood pressure lowering with the antihypertensive combination is also possible.
What this interaction means in plain words
Fentanyl intranasal and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced ADH release and additive hypotensive effects; the combined effect is pharmacodynamic.
What to do
Monitor blood pressure, fluid status and urine output when fentanyl is started or the dose is changed. Adjust antihypertensive therapy if hypotension or fluid retention occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fentanyl intranasal and Hydrochlorothiazide-irbesartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Fentanyl intranasal with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as minor. Fentanyl intranasal and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can cause hypotension and may blunt diuretic effect via antidiuretic hormone release, while also causing urinary retention. Additive blood pressure lowering with the antihypertensive combination is also possible.
How serious is the interaction between Fentanyl intranasal and Hydrochlorothiazide-irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and urine output when fentanyl is started or the dose is changed. Adjust antihypertensive therapy if hypotension or fluid retention occurs.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
