Drug interactions
Fentanyl intranasal + Hydrochlorothiazide
Severity: Minor
Fentanyl intranasal and Hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as fentanyl can promote antidiuretic hormone release and urinary retention, which may reduce the diuretic effect of hydrochlorothiazide. Opioid-related hypotension may also add to the diuretic effect.
What this interaction means in plain words
Fentanyl intranasal and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced ADH release and urinary retention oppose diuresis, with possible additive hypotension.
What to do
Monitor fluid balance, weight, urine output and blood pressure, and adjust the diuretic dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Fentanyl intranasal with Hydrochlorothiazide?
MediHelp rates the interaction as minor. Fentanyl intranasal and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids such as fentanyl can promote antidiuretic hormone release and urinary retention, which may reduce the diuretic effect of hydrochlorothiazide. Opioid-related hypotension may also add to the diuretic effect.
How serious is the interaction between Fentanyl intranasal and Hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fluid balance, weight, urine output and blood pressure, and adjust the diuretic dose if needed.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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