Drug interactions
Fentanyl intranasal + Metolazone
Severity: Minor
Fentanyl intranasal and Metolazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl may promote antidiuretic hormone release and cause urinary retention, which can blunt diuretic response. It can also add to hypotension in volume-depleted patients.
What this interaction means in plain words
Fentanyl intranasal and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced ADH release and urinary retention oppose diuresis; additive hypotensive effects.
What to do
Monitor urine output, weight and blood pressure, and adjust the metolazone dose if diuretic response declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metolazone
Frequently asked questions
Can I take Fentanyl intranasal with Metolazone?
MediHelp rates the interaction as minor. Fentanyl intranasal and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fentanyl may promote antidiuretic hormone release and cause urinary retention, which can blunt diuretic response. It can also add to hypotension in volume-depleted patients.
How serious is the interaction between Fentanyl intranasal and Metolazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urine output, weight and blood pressure, and adjust the metolazone dose if diuretic response declines.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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