Drug interactions
Fentanyl intranasal + Vortioxetine
Severity: Moderate
Fentanyl intranasal and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl has serotonergic activity, and serotonin syndrome has been reported with serotonergic antidepressants. Additive CNS and respiratory depression is also possible. Risk is higher with repeated dosing or higher doses.
What this interaction means in plain words
Fentanyl intranasal and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity, plus additive CNS depression.
What to do
Monitor for serotonin syndrome features such as clonus, agitation, tremor, and hyperthermia, particularly after starting or increasing doses. Use the lowest effective fentanyl dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Fentanyl intranasal with Vortioxetine?
MediHelp rates the interaction as moderate. Fentanyl intranasal and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fentanyl has serotonergic activity, and serotonin syndrome has been reported with serotonergic antidepressants. Additive CNS and respiratory depression is also possible. Risk is higher with repeated dosing or higher doses.
How serious is the interaction between Fentanyl intranasal and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome features such as clonus, agitation, tremor, and hyperthermia, particularly after starting or increasing doses. Use the lowest effective fentanyl dose.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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