Drug interactions
Fentanyl iontophoretic transdermal system + Fexofenadine
Severity: Minor
Fentanyl iontophoretic transdermal system and Fexofenadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexofenadine is minimally sedating and is expected to add little to fentanyl-related CNS depression. Clinically relevant additive sedation is unlikely.
What this interaction means in plain words
Fentanyl iontophoretic transdermal system and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Fexofenadine has negligible CNS penetration, so additive CNS depression is only theoretical.
What to do
No adjustment is required; monitor sedation and respiratory rate as for any opioid therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Frequently asked questions
Can I take Fentanyl iontophoretic transdermal system with Fexofenadine?
MediHelp rates the interaction as minor. Fentanyl iontophoretic transdermal system and Fexofenadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fexofenadine is minimally sedating and is expected to add little to fentanyl-related CNS depression. Clinically relevant additive sedation is unlikely.
How serious is the interaction between Fentanyl iontophoretic transdermal system and Fexofenadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is required; monitor sedation and respiratory rate as for any opioid therapy.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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