Drug interactions
Fentanyl iontophoretic transdermal system + Pregabalin
Severity: Major
Fentanyl iontophoretic transdermal system and Pregabalin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin together with the fentanyl iontophoretic system adds central nervous system depression, which may cause excessive sedation and slowed or shallow breathing. This is of particular concern in monitored postoperative patients who may also receive other sedating drugs.
What this interaction means in plain words
Fentanyl iontophoretic transdermal system and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central nervous system and respiratory depressant effects through different pharmacodynamic pathways.
What to do
Use the pregabalin at the lowest effective dose and monitor sedation and respiratory status continuously. Consider reducing the opioid demand with non-sedating analgesics.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pregabalin
Frequently asked questions
Can I take Fentanyl iontophoretic transdermal system with Pregabalin?
MediHelp rates the interaction as major. Fentanyl iontophoretic transdermal system and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pregabalin together with the fentanyl iontophoretic system adds central nervous system depression, which may cause excessive sedation and slowed or shallow breathing. This is of particular concern in monitored postoperative patients who may also receive other sedating drugs.
How serious is the interaction between Fentanyl iontophoretic transdermal system and Pregabalin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the pregabalin at the lowest effective dose and monitor sedation and respiratory status continuously. Consider reducing the opioid demand with non-sedating analgesics.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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