Drug interactions
Fentanyl iontophoretic transdermal system + Risperidone
Severity: Moderate
Fentanyl iontophoretic transdermal system and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids and antipsychotics both depress the central nervous system, so together they can cause excess sedation, hypotension and respiratory depression. The risk is highest in opioid-naive or older patients.
What this interaction means in plain words
Fentanyl iontophoretic transdermal system and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression, with additive hypotension from alpha-blockade.
What to do
Monitor sedation, respiratory rate and blood pressure, and counsel patients about drowsiness; reduce the opioid dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Fentanyl iontophoretic transdermal system with Risperidone?
MediHelp rates the interaction as moderate. Fentanyl iontophoretic transdermal system and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids and antipsychotics both depress the central nervous system, so together they can cause excess sedation, hypotension and respiratory depression. The risk is highest in opioid-naive or older patients.
How serious is the interaction between Fentanyl iontophoretic transdermal system and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory rate and blood pressure, and counsel patients about drowsiness; reduce the opioid dose if excessive sedation occurs.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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