Drug interactions
Fentanyl iontophoretic transdermal system + Vigabatrin
Severity: Moderate
Fentanyl iontophoretic transdermal system and Vigabatrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl causes sedation and respiratory depression, and vigabatrin independently causes somnolence. Together they may produce additive CNS depression.
What this interaction means in plain words
Fentanyl iontophoretic transdermal system and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression through pharmacodynamic effects.
What to do
Monitor for excess sedation and slowed breathing, and keep fentanyl doses as low as effective. Counsel the patient about impaired alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vigabatrin
- Amisulpride + Vigabatrin Moderate
- Asenapine transdermal + Vigabatrin Moderate
- Asenapine + Vigabatrin Moderate
- Avapritinib + Vigabatrin Moderate
- Benzhydrocodone / acetaminophen + Vigabatrin Moderate
- Brexanolone + Vigabatrin Moderate
Frequently asked questions
Can I take Fentanyl iontophoretic transdermal system with Vigabatrin?
MediHelp rates the interaction as moderate. Fentanyl iontophoretic transdermal system and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fentanyl causes sedation and respiratory depression, and vigabatrin independently causes somnolence. Together they may produce additive CNS depression.
How serious is the interaction between Fentanyl iontophoretic transdermal system and Vigabatrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and slowed breathing, and keep fentanyl doses as low as effective. Counsel the patient about impaired alertness.
What other medicines interact with Vigabatrin?
MediHelp also lists interactions of Vigabatrin with, for example, Amisulpride, Asenapine transdermal, Asenapine. The full list is on the Vigabatrin page.
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