Drug interactions
Fentanyl transdermal + Zileuton
Severity: Moderate
Fentanyl transdermal and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl is cleared mainly by CYP3A4, and zileuton can weakly inhibit this pathway. Because transdermal fentanyl has a long depot effect, increased exposure may cause prolonged sedation and respiratory depression.
What this interaction means in plain words
Fentanyl transdermal and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Zileuton inhibition of CYP3A4 metabolism of fentanyl.
What to do
Monitor for sedation and respiratory depression for several days after starting or stopping zileuton. Reduce the fentanyl patch strength if opioid toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Frequently asked questions
Can I take Fentanyl transdermal with Zileuton?
MediHelp rates the interaction as moderate. Fentanyl transdermal and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fentanyl is cleared mainly by CYP3A4, and zileuton can weakly inhibit this pathway. Because transdermal fentanyl has a long depot effect, increased exposure may cause prolonged sedation and respiratory depression.
How serious is the interaction between Fentanyl transdermal and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression for several days after starting or stopping zileuton. Reduce the fentanyl patch strength if opioid toxicity occurs.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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