Drug interactions
Fentanyl transmucosal + Vortioxetine
Severity: Moderate
Fentanyl transmucosal and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl has serotonergic activity, and serotonin syndrome has been reported with serotonergic antidepressants. Rapid transmucosal absorption gives high peak levels, and additive CNS and respiratory depression may occur.
What this interaction means in plain words
Fentanyl transmucosal and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity, plus additive CNS depression.
What to do
Monitor for serotonin syndrome and respiratory depression, particularly during dose titration. Use the lowest effective fentanyl dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fentanyl transmucosal and Vortioxetine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Fentanyl transmucosal with Vortioxetine?
MediHelp rates the interaction as moderate. Fentanyl transmucosal and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fentanyl has serotonergic activity, and serotonin syndrome has been reported with serotonergic antidepressants. Rapid transmucosal absorption gives high peak levels, and additive CNS and respiratory depression may occur.
How serious is the interaction between Fentanyl transmucosal and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome and respiratory depression, particularly during dose titration. Use the lowest effective fentanyl dose.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
