Drug interactions
Ferrous fumarate + Vadadustat
Severity: Moderate
Ferrous fumarate and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iron salts bind vadadustat in the gut and lower its absorption. This may reduce its effect on hemoglobin in anemia of chronic kidney disease.
What this interaction means in plain words
Ferrous fumarate and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ferrous fumarate belongs to Miscellaneous; Vadadustat belongs to Endocrine.
Why it happens
Iron cations bind vadadustat in the gastrointestinal tract, reducing its absorption.
What to do
Take vadadustat at least 1 hour before oral iron or iron-containing phosphate binders. Monitor hemoglobin response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ferrous fumarate
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Ferrous fumarate with Vadadustat?
MediHelp rates the interaction as moderate. Ferrous fumarate and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iron salts bind vadadustat in the gut and lower its absorption. This may reduce its effect on hemoglobin in anemia of chronic kidney disease.
How serious is the interaction between Ferrous fumarate and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take vadadustat at least 1 hour before oral iron or iron-containing phosphate binders. Monitor hemoglobin response.
What other medicines interact with Ferrous fumarate?
MediHelp also lists interactions of Ferrous fumarate with, for example, Ciprofloxacin, Acetohydroxamic acid, Aluminum hydroxide. The full list is on the Ferrous fumarate page.
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