Drug interactions
Ferrous sulfate + Vadadustat
Severity: Moderate
Ferrous sulfate and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron salts bind vadadustat in the gut and reduce its absorption. This can lower vadadustat exposure and weaken its effect on anemia of chronic kidney disease.
What this interaction means in plain words
Ferrous sulfate and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ferrous sulfate belongs to Miscellaneous; Vadadustat belongs to Endocrine.
Why it happens
Iron cations chelate vadadustat in the gastrointestinal tract, decreasing its absorption.
What to do
Take vadadustat at least 1 hour before oral iron or iron-containing phosphate binders. Monitor hemoglobin response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ferrous sulfate
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Ferrous sulfate with Vadadustat?
MediHelp rates the interaction as moderate. Ferrous sulfate and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron salts bind vadadustat in the gut and reduce its absorption. This can lower vadadustat exposure and weaken its effect on anemia of chronic kidney disease.
How serious is the interaction between Ferrous sulfate and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take vadadustat at least 1 hour before oral iron or iron-containing phosphate binders. Monitor hemoglobin response.
What other medicines interact with Ferrous sulfate?
MediHelp also lists interactions of Ferrous sulfate with, for example, Ciprofloxacin, Dimercaprol, Acetohydroxamic acid. The full list is on the Ferrous sulfate page.
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