Drug interactions
Fesoterodine + Fluconazole
Severity: Minor
Fesoterodine and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole is a moderate CYP3A4 inhibitor and can increase exposure to the active metabolite of fesoterodine. This may increase antimuscarinic adverse effects.
What this interaction means in plain words
Fesoterodine and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fesoterodine belongs to Genitourinary; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4, reducing clearance of the active fesoterodine metabolite.
What to do
No routine dose change; monitor for anticholinergic effects such as dry mouth and constipation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fesoterodine
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fesoterodine with Fluconazole?
MediHelp rates the interaction as minor. Fesoterodine and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole is a moderate CYP3A4 inhibitor and can increase exposure to the active metabolite of fesoterodine. This may increase antimuscarinic adverse effects.
How serious is the interaction between Fesoterodine and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for anticholinergic effects such as dry mouth and constipation.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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