Drug interactions
Fesoterodine + Fluphenazine
Severity: Moderate
Fesoterodine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine has anticholinergic activity that adds to that of fesoterodine, increasing risk of dry mouth, constipation, urinary retention and confusion. The effect is generally less than with more strongly anticholinergic antipsychotics.
What this interaction means in plain words
Fesoterodine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects at muscarinic receptors.
What to do
Monitor for anticholinergic adverse effects, especially bowel function and urinary retention, and in older patients consider lowering the overall anticholinergic burden.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fesoterodine with Fluphenazine?
MediHelp rates the interaction as moderate. Fesoterodine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine has anticholinergic activity that adds to that of fesoterodine, increasing risk of dry mouth, constipation, urinary retention and confusion. The effect is generally less than with more strongly anticholinergic antipsychotics.
How serious is the interaction between Fesoterodine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, especially bowel function and urinary retention, and in older patients consider lowering the overall anticholinergic burden.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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