Drug interactions
Fesoterodine + Fosaprepitant
Severity: Minor
Fesoterodine and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is given as a short single-dose course and produces only weak, transient CYP3A4 inhibition. Any rise in fesoterodine metabolite exposure is expected to be small.
What this interaction means in plain words
Fesoterodine and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fesoterodine belongs to Genitourinary; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Weak, transient CYP3A4 inhibition by aprepitant, the active form of fosaprepitant.
What to do
No dose adjustment is needed; monitor for anticholinergic effects around the time of dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fesoterodine
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fesoterodine with Fosaprepitant?
MediHelp rates the interaction as minor. Fesoterodine and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant is given as a short single-dose course and produces only weak, transient CYP3A4 inhibition. Any rise in fesoterodine metabolite exposure is expected to be small.
How serious is the interaction between Fesoterodine and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for anticholinergic effects around the time of dosing.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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