Drug interactions
Fesoterodine + Haloperidol
Severity: Moderate
Fesoterodine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can produce anticholinergic effects, so combining them may add to dry mouth, constipation, urinary retention, blurred vision and confusion. Delayed gastric emptying from fesoterodine could modestly alter oral haloperidol absorption, but the main concern is additive anticholinergic burden, especially in older adults.
What this interaction means in plain words
Fesoterodine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Haloperidol belongs to Central Nervous System.
Why it happens
Additive antimuscarinic pharmacodynamic effects, since haloperidol has weak anticholinergic activity.
What to do
Monitor for anticholinergic adverse effects, urinary retention and cognitive change, especially in elderly patients. Use the lowest effective doses of each agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Fesoterodine with Haloperidol?
MediHelp rates the interaction as moderate. Fesoterodine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can produce anticholinergic effects, so combining them may add to dry mouth, constipation, urinary retention, blurred vision and confusion. Delayed gastric emptying from fesoterodine could modestly alter oral haloperidol absorption, but the main concern is additive anticholinergic burden, especially in older adults.
How serious is the interaction between Fesoterodine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, urinary retention and cognitive change, especially in elderly patients. Use the lowest effective doses of each agent.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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