Drug interactions
Fesoterodine + Indacaterol-glycopyrronium
Severity: Moderate
Fesoterodine and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fesoterodine is an antimuscarinic for overactive bladder, and glycopyrronium is an inhaled antimuscarinic. Additive anticholinergic effects such as dry mouth, constipation, urinary retention and blurred vision may occur. Systemic glycopyrronium exposure is low, but the effect may be relevant in older patients.
What this interaction means in plain words
Fesoterodine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic adverse effects, especially urinary retention and constipation. Reduce the dose or stop one agent if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Fesoterodine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fesoterodine is an antimuscarinic for overactive bladder, and glycopyrronium is an inhaled antimuscarinic. Additive anticholinergic effects such as dry mouth, constipation, urinary retention and blurred vision may occur. Systemic glycopyrronium exposure is low, but the effect may be relevant in older patients.
How serious is the interaction between Fesoterodine and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, especially urinary retention and constipation. Reduce the dose or stop one agent if symptoms develop.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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