Drug interactions
Fesoterodine + Solifenacin
Severity: Moderate
Fesoterodine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are antimuscarinics for overactive bladder, so combining them duplicates therapy and adds to dry mouth, constipation, blurred vision, urinary retention and cognitive effects without proven benefit.
What this interaction means in plain words
Fesoterodine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Solifenacin belongs to Genitourinary.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid concurrent use; optimize one agent or switch to a different class. If overlap is unavoidable, monitor for anticholinergic toxicity and retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Solifenacin?
MediHelp rates the interaction as moderate. Fesoterodine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are antimuscarinics for overactive bladder, so combining them duplicates therapy and adds to dry mouth, constipation, blurred vision, urinary retention and cognitive effects without proven benefit.
How serious is the interaction between Fesoterodine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; optimize one agent or switch to a different class. If overlap is unavoidable, monitor for anticholinergic toxicity and retention.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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