Drug interactions
Fesoterodine + Voriconazole
Severity: Moderate
Fesoterodine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole is a strong CYP3A4 inhibitor and can substantially raise exposure to fesoterodine's active metabolite. This increases risk of antimuscarinic adverse effects, particularly with CYP2D6 poor metabolism or renal or hepatic impairment.
What this interaction means in plain words
Fesoterodine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated clearance of 5-hydroxymethyl tolterodine.
What to do
Limit fesoterodine to the labeled maximum dose (4 mg daily) with strong CYP3A4 inhibitors. Monitor for antimuscarinic adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Fesoterodine with Voriconazole?
MediHelp rates the interaction as moderate. Fesoterodine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole is a strong CYP3A4 inhibitor and can substantially raise exposure to fesoterodine's active metabolite. This increases risk of antimuscarinic adverse effects, particularly with CYP2D6 poor metabolism or renal or hepatic impairment.
How serious is the interaction between Fesoterodine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit fesoterodine to the labeled maximum dose (4 mg daily) with strong CYP3A4 inhibitors. Monitor for antimuscarinic adverse effects.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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