Drug interactions
Fexinidazole + Goserelin
Severity: Major
Fexinidazole and Goserelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole prolongs the QT interval and its labeling advises avoiding other QT-prolonging drugs. Goserelin adds a further QT-lengthening tendency, increasing the risk of torsades de pointes.
What this interaction means in plain words
Fexinidazole and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination where possible. If goserelin cannot be stopped, perform ECG monitoring and correct potassium and magnesium before and during fexinidazole therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Goserelin
Frequently asked questions
Can I take Fexinidazole with Goserelin?
MediHelp rates the interaction as major. Fexinidazole and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole prolongs the QT interval and its labeling advises avoiding other QT-prolonging drugs. Goserelin adds a further QT-lengthening tendency, increasing the risk of torsades de pointes.
How serious is the interaction between Fexinidazole and Goserelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If goserelin cannot be stopped, perform ECG monitoring and correct potassium and magnesium before and during fexinidazole therapy.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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