Drug interactions
Fexinidazole + Hydroxychloroquine
Severity: Major
Fexinidazole and Hydroxychloroquine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole can prolong the QT interval, and the labeling advises against combining it with other QT-prolonging drugs. Adding hydroxychloroquine increases the risk of torsades de pointes.
What this interaction means in plain words
Fexinidazole and Hydroxychloroquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive blockade of cardiac repolarizing potassium channels produces additive QT prolongation.
What to do
Avoid coadministration. If hydroxychloroquine cannot be stopped, perform ECG monitoring and correct potassium, magnesium and calcium before and during fexinidazole treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Fexinidazole with Hydroxychloroquine?
MediHelp rates the interaction as major. Fexinidazole and Hydroxychloroquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole can prolong the QT interval, and the labeling advises against combining it with other QT-prolonging drugs. Adding hydroxychloroquine increases the risk of torsades de pointes.
How serious is the interaction between Fexinidazole and Hydroxychloroquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. If hydroxychloroquine cannot be stopped, perform ECG monitoring and correct potassium, magnesium and calcium before and during fexinidazole treatment.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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