Drug interactions
Fexinidazole + Lacosamide
Severity: Minor
Fexinidazole and Lacosamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4, and lacosamide is metabolized partly by CYP3A4, CYP2C9 and CYP2C19. Any increase in lacosamide exposure is likely modest but could add to dizziness and PR interval prolongation.
What this interaction means in plain words
Fexinidazole and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible mild inhibition of CYP3A4 by fexinidazole, a minor pathway for lacosamide.
What to do
No routine dose change is needed. Monitor for dizziness, ataxia and cardiac conduction symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Fexinidazole with Lacosamide?
MediHelp rates the interaction as minor. Fexinidazole and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fexinidazole may inhibit CYP3A4, and lacosamide is metabolized partly by CYP3A4, CYP2C9 and CYP2C19. Any increase in lacosamide exposure is likely modest but could add to dizziness and PR interval prolongation.
How serious is the interaction between Fexinidazole and Lacosamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for dizziness, ataxia and cardiac conduction symptoms.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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