Drug interactions
Fexinidazole + Modafinil
Severity: Moderate
Fexinidazole and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4 and may increase modafinil concentrations, increasing its adverse effects. Both drugs can also cause neuropsychiatric effects such as insomnia and anxiety, and fexinidazole prolongs QT, so tolerability needs attention.
What this interaction means in plain words
Fexinidazole and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4-mediated metabolism of modafinil.
What to do
Monitor for neuropsychiatric effects and blood pressure, and consider holding or reducing modafinil during the short fexinidazole course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Fexinidazole with Modafinil?
MediHelp rates the interaction as moderate. Fexinidazole and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole inhibits CYP3A4 and may increase modafinil concentrations, increasing its adverse effects. Both drugs can also cause neuropsychiatric effects such as insomnia and anxiety, and fexinidazole prolongs QT, so tolerability needs attention.
How serious is the interaction between Fexinidazole and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropsychiatric effects and blood pressure, and consider holding or reducing modafinil during the short fexinidazole course.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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