Drug interactions
Fexinidazole + Nevirapine
Severity: Moderate
Fexinidazole and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and raise nevirapine levels, increasing risk of adverse effects such as hepatotoxicity and rash. Nevirapine may in turn alter fexinidazole exposure through induction.
What this interaction means in plain words
Fexinidazole and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, while nevirapine induces CYP3A4 and may affect fexinidazole metabolism.
What to do
Monitor liver enzymes and for nevirapine toxicity during fexinidazole treatment. Consider an alternative if hepatic abnormalities develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Fexinidazole with Nevirapine?
MediHelp rates the interaction as moderate. Fexinidazole and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and raise nevirapine levels, increasing risk of adverse effects such as hepatotoxicity and rash. Nevirapine may in turn alter fexinidazole exposure through induction.
How serious is the interaction between Fexinidazole and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and for nevirapine toxicity during fexinidazole treatment. Consider an alternative if hepatic abnormalities develop.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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