Drug interactions
Fexinidazole + Oxycodone
Severity: Moderate
Fexinidazole and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and could increase oxycodone exposure, raising the risk of opioid toxicity. Fexinidazole is used for a short course.
What this interaction means in plain words
Fexinidazole and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated oxycodone metabolism.
What to do
Monitor for sedation and respiratory depression and consider reducing the oxycodone dose during fexinidazole therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Fexinidazole with Oxycodone?
MediHelp rates the interaction as moderate. Fexinidazole and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and could increase oxycodone exposure, raising the risk of opioid toxicity. Fexinidazole is used for a short course.
How serious is the interaction between Fexinidazole and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and consider reducing the oxycodone dose during fexinidazole therapy.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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