Drug interactions
Fexinidazole + Ruxolitinib
Severity: Moderate
Fexinidazole and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and increase ruxolitinib exposure. This may increase cytopenias and infection risk, although the magnitude is not well defined.
What this interaction means in plain words
Fexinidazole and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by fexinidazole reduces ruxolitinib metabolism.
What to do
Monitor blood counts during the short fexinidazole course. Consider a ruxolitinib dose reduction if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ruxolitinib
Frequently asked questions
Can I take Fexinidazole with Ruxolitinib?
MediHelp rates the interaction as moderate. Fexinidazole and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and increase ruxolitinib exposure. This may increase cytopenias and infection risk, although the magnitude is not well defined.
How serious is the interaction between Fexinidazole and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts during the short fexinidazole course. Consider a ruxolitinib dose reduction if cytopenias develop.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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