Drug interactions
Fexinidazole + Sotalol
Severity: Major
Fexinidazole and Sotalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole can prolong the QT interval, and sotalol does so as well while also slowing heart rate. Together they raise the risk of torsades de pointes and bradyarrhythmia.
What this interaction means in plain words
Fexinidazole and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation and bradycardic effects (pharmacodynamic synergism).
What to do
Avoid coadministration; if sotalol cannot be stopped, perform ECG monitoring and correct electrolytes before and during fexinidazole treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Fexinidazole with Sotalol?
MediHelp rates the interaction as major. Fexinidazole and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole can prolong the QT interval, and sotalol does so as well while also slowing heart rate. Together they raise the risk of torsades de pointes and bradyarrhythmia.
How serious is the interaction between Fexinidazole and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; if sotalol cannot be stopped, perform ECG monitoring and correct electrolytes before and during fexinidazole treatment.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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