Drug interactions
Fexinidazole + Tiotropium-olodaterol
Severity: Major
Fexinidazole and Tiotropium-olodaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole prolongs the QT interval and olodaterol, a beta-agonist, can add to QT and heart rate effects and lower potassium. The risk of torsades de pointes is increased.
What this interaction means in plain words
Fexinidazole and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia as a further risk factor.
What to do
Avoid if possible; otherwise obtain a baseline ECG, correct electrolytes and monitor the ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tiotropium-olodaterol
Frequently asked questions
Can I take Fexinidazole with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Fexinidazole and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole prolongs the QT interval and olodaterol, a beta-agonist, can add to QT and heart rate effects and lower potassium. The risk of torsades de pointes is increased.
How serious is the interaction between Fexinidazole and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain a baseline ECG, correct electrolytes and monitor the ECG.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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