Drug interactions
Fexinidazole + Tramadol
Severity: Moderate
Fexinidazole and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4, which contributes to tramadol N-demethylation, potentially raising tramadol exposure. Higher tramadol levels may increase opioid and serotonergic effects and seizure risk, though CYP2D6 pathway shifts may also alter analgesia.
What this interaction means in plain words
Fexinidazole and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated tramadol metabolism, shifting disposition.
What to do
Monitor for sedation, respiratory depression, and seizure or serotonin toxicity; consider lower tramadol doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Fexinidazole with Tramadol?
MediHelp rates the interaction as moderate. Fexinidazole and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4, which contributes to tramadol N-demethylation, potentially raising tramadol exposure. Higher tramadol levels may increase opioid and serotonergic effects and seizure risk, though CYP2D6 pathway shifts may also alter analgesia.
How serious is the interaction between Fexinidazole and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression, and seizure or serotonin toxicity; consider lower tramadol doses.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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