Drug interactions
Fexinidazole + Vortioxetine
Severity: Moderate
Fexinidazole and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole and its metabolites may inhibit CYP3A4, which could raise vortioxetine exposure. Higher concentrations can increase nausea and other dose-related adverse effects, and may add to serotonergic or QT-related concerns in a patient who is already receiving other risk-bearing drugs.
What this interaction means in plain words
Fexinidazole and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 by fexinidazole may reduce the minor CYP3A4-mediated clearance of vortioxetine; vortioxetine is cleared mainly via CYP2D6, so the effect is likely modest.
What to do
Monitor for vortioxetine adverse effects such as nausea, agitation and dizziness during the short fexinidazole course. Consider lowering the vortioxetine dose if tolerability problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Fexinidazole with Vortioxetine?
MediHelp rates the interaction as moderate. Fexinidazole and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole and its metabolites may inhibit CYP3A4, which could raise vortioxetine exposure. Higher concentrations can increase nausea and other dose-related adverse effects, and may add to serotonergic or QT-related concerns in a patient who is already receiving other risk-bearing drugs.
How serious is the interaction between Fexinidazole and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for vortioxetine adverse effects such as nausea, agitation and dizziness during the short fexinidazole course. Consider lowering the vortioxetine dose if tolerability problems arise.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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