Drug interactions
Fexinidazole + Zonisamide
Severity: Moderate
Fexinidazole and Zonisamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zonisamide is partly metabolized by CYP3A4, so inhibition may raise its levels. Fexinidazole is given only for a short course, and the clinical impact is probably modest but could cause more adverse effects such as somnolence.
What this interaction means in plain words
Fexinidazole and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole and its metabolites inhibit CYP3A4, reducing zonisamide clearance.
What to do
Monitor for zonisamide toxicity such as sedation, ataxia and confusion during the fexinidazole course. Reduce the zonisamide dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Fexinidazole with Zonisamide?
MediHelp rates the interaction as moderate. Fexinidazole and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zonisamide is partly metabolized by CYP3A4, so inhibition may raise its levels. Fexinidazole is given only for a short course, and the clinical impact is probably modest but could cause more adverse effects such as somnolence.
How serious is the interaction between Fexinidazole and Zonisamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for zonisamide toxicity such as sedation, ataxia and confusion during the fexinidazole course. Reduce the zonisamide dose if symptoms occur.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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