Drug interactions
Fexofenadine + Midazolam intranasal
Severity: Minor
Fexofenadine and Midazolam intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam causes dose-related sedation and respiratory depression, which are potentiated by other CNS depressants. Fexofenadine is minimally sedating, so the additive risk is low.
What this interaction means in plain words
Fexofenadine and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression; fexofenadine has negligible central activity.
What to do
No change is needed; monitor sedation and respiratory status as for any midazolam use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Frequently asked questions
Can I take Fexofenadine with Midazolam intranasal?
MediHelp rates the interaction as minor. Fexofenadine and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Midazolam causes dose-related sedation and respiratory depression, which are potentiated by other CNS depressants. Fexofenadine is minimally sedating, so the additive risk is low.
How serious is the interaction between Fexofenadine and Midazolam intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is needed; monitor sedation and respiratory status as for any midazolam use.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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