Drug interactions
Fexofenadine + Nefazodone
Severity: Minor
Fexofenadine and Nefazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone inhibits P-glycoprotein to a limited degree and could modestly raise fexofenadine levels. The clinical importance is likely small given fexofenadine's safety margin.
What this interaction means in plain words
Fexofenadine and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-glycoprotein inhibition by nefazodone reduces fexofenadine efflux.
What to do
No dose change is needed; monitor for dizziness or other antihistamine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fexofenadine
- Danicopan + Fexofenadine Moderate
- Erdafitinib + Fexofenadine Moderate
- Fexofenadine + Glecaprevir / pibrentasvir Moderate
- Fexofenadine + Grapefruit Moderate
- Fexofenadine + Juice Moderate
- Acrivastine + Fexofenadine Minor
Frequently asked questions
Can I take Fexofenadine with Nefazodone?
MediHelp rates the interaction as minor. Fexofenadine and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nefazodone inhibits P-glycoprotein to a limited degree and could modestly raise fexofenadine levels. The clinical importance is likely small given fexofenadine's safety margin.
How serious is the interaction between Fexofenadine and Nefazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for dizziness or other antihistamine adverse effects.
What other medicines interact with Fexofenadine?
MediHelp also lists interactions of Fexofenadine with, for example, Danicopan, Erdafitinib, Glecaprevir / pibrentasvir. The full list is on the Fexofenadine page.
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