Drug interactions
Fezolinetant + Interferon alfa 2b
Severity: Moderate
Fezolinetant and Interferon alfa 2b: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fezolinetant is metabolized mainly by CYP1A2, and CYP1A2 inhibitors raise its exposure and the risk of liver injury. Interferons can reduce CYP1A2 activity modestly, but this is far weaker than the inhibitors addressed by the contraindication, and interferon-related liver effects also matter.
What this interaction means in plain words
Fezolinetant and Interferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fezolinetant belongs to Endocrine; Interferon alfa 2b belongs to Anti Virals.
Why it happens
Interferon alfa may suppress CYP1A2 activity, modestly reducing fezolinetant clearance.
What to do
Check liver function tests before starting fezolinetant and monitor them during combined therapy. Stop fezolinetant if signs of liver injury develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Interferon alfa 2b
Other interactions of Fezolinetant
- Cimetidine + Fezolinetant Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
Frequently asked questions
Can I take Fezolinetant with Interferon alfa 2b?
MediHelp rates the interaction as moderate. Fezolinetant and Interferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fezolinetant is metabolized mainly by CYP1A2, and CYP1A2 inhibitors raise its exposure and the risk of liver injury. Interferons can reduce CYP1A2 activity modestly, but this is far weaker than the inhibitors addressed by the contraindication, and interferon-related liver effects also matter.
How serious is the interaction between Fezolinetant and Interferon alfa 2b?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver function tests before starting fezolinetant and monitor them during combined therapy. Stop fezolinetant if signs of liver injury develop.
What other medicines interact with Interferon alfa 2b?
MediHelp also lists interactions of Interferon alfa 2b with, for example, Deferiprone, Hydroxyurea, Pexidartinib. The full list is on the Interferon alfa 2b page.
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